Evidence that immunization with TP0751, a bipartite Treponema pallidum lipoprotein with an intrinsically disordered region and lipocalin fold, fails to protect in the rabbit model of experimental syphilis
Fig 5
TP075197-228 and Tpp17 share similar structural topologies.
The upper panel shows ribbon diagrams for the structures of TP075197-228 (PDB ID: 5JK2), Tpp17 (PDB ID:4U3Q), and the N-terminal domain (residues 21–103) of E. coli NlpE (PDB ID:4Z4H) (all in the same orientation). The Ω-type loops are shown in orange. Residues of the calycin signature motif are shown as blue sticks and labeled. The lower panel presents secondary structure topology diagrams. β-strands and α-helices are represented by arrows and cylinders, respectively. N- and C-termini are indicated, and the ‘Ω-type’ loops shared by TP075197-228 and Tpp17 are labeled.