Nicotinic acetylcholine receptors: Ex-vivo expression of functional, non-hybrid, heteropentameric receptors from a marine arthropod, Lepeophtheirus salmonis
Fig 5
Effect of two different α:β ratio on Lsa-nAChR1 and Lsa-nAChR2 sensitivity to sazetidin A (Saz A) and dihydro-β-erythroidine (DHbE).
Typical current traces obtained with 10 μM Saz A (A and C) or 10 μM DHbE (B and D) obtained from oocytes expressing two different ratios of α:β Lsa-nAChR1 (A and B) or Lsa-nAChR2 (C and D) are shown. The bars indicate the time period of ACh (black line), Saz A (interrupted line), or DHbE (grey line). The traces obtained with Saz A are also represented with a smaller scale to allow a better visualization of the peak currents recorded.