Pyrrocidine, a molecular off switch for fumonisin biosynthesis
Fig 2
Functional catalog of pyrrocidine-responsive genes.
Function enrichment analysis was conducted with MIPS FunCat Server (http://mips.helmholtz-muenchen.de/funcatDB/) [14]. The five club shapes correspond to the following MIPS functional categories: metabolism (01), cellular transport (20), cellular communication/signal transduction mechanism (30), cell rescue, defense and virulence (32), and interaction with the environment (34). The numbers of genes functionally enriched in the different categories are included, and genes with multifunctional enrichment are shown in overlapping regions. Of 525 pyrrocidine-responsive genes, 196 genes were functionally enriched in these five different categories after applying a filter of p-value < 0.05. FvABC3 is one of nine genes that functionally span four different enriched categories (01, 20, 32, 34), and FvZBD1 is functionally enriched only in metabolism along with another 80 genes.