Hepatitis B virus Core protein nuclear interactome identifies SRSF10 as a host RNA-binding protein restricting HBV RNA production
Fig 5
Effect of 1C8 on an established HBV infection.
(A) Molecular structure of 1C8. (B) Outline of the experimental protocol: HBV-infected dHepaRG cells (C) or PHH (D) were treated three times with Tenofovir (TDF at 10μM), a Core allosteric modulator (CAM at 10μM) or 1C8 (10 μM) starting at D4pi. Intracellular and secreted HBV parameters were quantified 2 days after the last treatment. Results are expressed as the mean normalized ratio +/- SD between non-treated and treated cells of 3 independent experiments, each performed in triplicate.