Hepatitis B virus Core protein nuclear interactome identifies SRSF10 as a host RNA-binding protein restricting HBV RNA production
Fig 2
(A) Proteins significantly associated to HBc in the presence of Benzonase were analyzed using the Genemania plugin in Cytoscape (3.7.1). Red lines indicate known physical interactions. Missing nodes are indicated by grey circles. (B) Interaction network of proteins involved in mRNA splicing via spliceosome. Significant proteins, common to the Benzonase-/+ conditions, over-representing the mRNA splicing via spliceosome biological process (“founder proteins” highlighted as orange nodes) were used to initiate the network by querying IntAct database. Red, blue and green nodes denote protein of the computed network that are found in the proteomic hits of both Benzonase-/+ (Benz- or Benz+) conditions. Nodes with a bold border indicate significant proteins (p-value<0.005 and fold change>4) from the proteomics data.