Fluorescent protein tagging of adenoviral proteins pV and pIX reveals ‘late virion accumulation compartment’
Fig 9
Model of late virion accumulation compartment (LVAC) formation and localization of viral proteins within.
The nucleus is represented as a grey ellipse. At 24 hpi, pV is located around DBP replication centers in areas accumulating replicated genomes. At this timepoint, pIX was not found in the nucleus but was instead localized in the cytoplasm (not displayed in model). During transition between 24 and 48 hpi the viral proteins congregated to form the LVAC. Within the LVAC, pIX spots indicate the areas of accumulated assembled virus capsids in areas neighboring viral genomes and pV. Each protein localization is accompanied by a fluorescence microscopy image of the protein observed in our study.