Murine cytomegaloviruses m139 targets DDX3 to curtail interferon production and promote viral replication
Fig 2
MCMV m139 is important for viral replication in macrophages and endothelial cells.
Multistep replication kinetics of WT MCMV, MCMV m139-HA and MCMV m139stop in murine 10.1 fibroblasts (A), TCMK-1 epithelial cells (B), SVEC4-10 endothelial cells (C), and immortalized bone marrow-derived macrophages (iBMDM) (D). iBMDM were infected at an MOI of 0.025, all others at an MOI of 0.01. Virus released by infected cells into the supernatant was quantified by titration. Viral titers are shown as means ±SD of three biological replicates.