Triclosan depletes the membrane potential in Pseudomonas aeruginosa biofilms inhibiting aminoglycoside induced adaptive resistance
Fig 2
Mutants from experimental evolution are resistant to tobramycin and the combination.
24-hr old biofilms were treated with triclosan (100 μM) and tobramycin (500 μM) alone and in combination. The results represent the means plus SD (n = 6). A two-way ANOVA followed by Tukey’s posttest was used to determine statistical significance within each group compared to the untreated control for each strain. p<0.05.