Role of Hepatitis B virus capsid phosphorylation in nucleocapsid disassembly and covalently closed circular DNA formation
Fig 9
Effects of CDK2 inhibitors on CCC DNA formation during HBV infection.
The PXB cells were infected with HBV and treated with the CDK2 inhibitor K03861 at the indicated concentrations (A) or CDK2 inhibitor III (CDK2i III; 125 nM) (B) at the same time. HBV PF DNA was extracted from the cells three days after infection and measured by Southern blot analysis using a 32P-labeled HBV DNA probe. Shown are representative Southern blot autoradiograms (phosphorimaging scan) of PF DNA, with the relative levels of CCC DNA indicated at the bottom and CCC DNA level from the mock-treated cells set to 1.0.