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An improved animal model for herpesvirus encephalitis in humans

Fig 7

Detection of viral antigen in mice infected with PrV-ΔUL21/US3Δkin.

Immunohistochemistry (anti PrV-gB) of the trigeminal ganglion (TG), brainstem (BS) and mesiotemporal lobe (MTL) are shown in A) 132–168 h p.i., B) 192–240 h p.i., C) 264 h p.i. and D) 288–360 h p.i. Positive staining is highlighted by arrows. A higher magnification of single infected neurons is shown in the inset in B) MTL.

Fig 7

doi: https://doi.org/10.1371/journal.ppat.1008445.g007