Baloxavir treatment of ferrets infected with influenza A(H1N1)pdm09 virus reduces onward transmission
Fig 2
Effect of BXA treatment on indirect transmission (London).
(A) Experimental setup. Donor ferrets were intranasally inoculated with 104 PFU of A/England/195/2009. Antiviral treatment of infected donor ferrets commenced 24 hours post-infection. OST was administered a total of ten times across a five-day period; BXA was delivered as a single dose. Influenza-naïve sentinel DC ferrets were co-housed immediately following treatment. In addition, naïve sentinel IC ferrets were housed immediately after treatment in separate cages from those of the donor and DC sentinel ferrets. Nasal washes were collected from all donor and sentinel ferrets to assess shedding of infectious virus from 1 DPE to 11 DPE. (B) Nasal wash infectious viral titres in donor and sentinel ferrets. Donor ferrets were either untreated (upper panel), treated with oseltamivir (OST, middle) or treated with baloxavir (BXA, lower). Virus replication curves (plaque assay) for each donor and their corresponding DC and IC sentinels are graphed.