A mosquito juvenile hormone binding protein (mJHBP) regulates the activation of innate immune defenses and hemocyte development
Fig 9
Effect of mJHBP deficiency on the expression of Toll, IMD, and JAK/STAT pathway components in response to bacterial challenge.
Gene expression comparison between WT and KO females for: A. IMD (IMD Pathway); B. STAT (JAK/STAT pathway), C. MyD88 (Toll pathway), D. Rel1 (Toll pathway), E. Rel2 (IMD pathway), F. Cactus (Toll pathway), G. Caspar (IMD pathway), H. PGRP-S1. Fat bodies of infected WT and KO mosquitoes were dissected at 6, 24, 48, and 72 h post-infection. Each time point represents 50 mosquitoes (5 biological replicates of 10 mosquitoes each). Significance levels (Mann-Whitney) are indicated with asterisks (p ** ≤ 0.01).