Ecotin, a microbial inhibitor of serine proteases, blocks multiple complement dependent and independent microbicidal activities of human serum
Fig 13
Occurrence of ecotin orthologs in the kingdoms of Eukaryota and Bacteria.
Orthologs of ecotin are present in both Eukaryota and Bacteria kingdoms. More than three hundred species express at least one ecotin homolog. Among eukaryotic species, the Trypanosomatidae, belonging to the Kinetoplastida class, contain several species that are causative agents of serious and widespread diseases (based on publicly available pathogen databases (see Materials and methods)), and 12 species of this genus express ecotin homologs (based on the PFAM database https://pfam.xfam.org). Among Bacteria two classes are exceptionally rich in ecotin expressing species: Bacteroidetes (40 species) and Proteobacteria (158 species). Numbers in bold indicate how many pathogens exist among the ecotin expressing species in that genera; while those in italic indicate how many pathogens are among all species in that genera. Figure was made based on PFAM (https://pfam.xfam.org).