Influenza viruses that require 10 genomic segments as antiviral therapeutics
Fig 5
Influenza viruses that require 10 genomic segments for infectivity are highly attenuated and their administration protects mice from wild-type viral challenge.
(A) Weight loss curves from infections with the indicated doses of 10S virus. (B) Survival curves from infections described in A. (C) Diagram detailing the coinfection challenge experimental design in C57BL/6J mice. (D) Bodyweight curves after infecting mice with a sublethal dose of the 10S virus (5000 PFU), a lethal dose of WT PR8 (20 PFU), or a combination of the WT PR8 and 10S viruses. (E) Survival curves from the infection groups described in D.