Pyruvate produced by Brugia spp. via glycolysis is essential for maintaining the mutualistic association between the parasite and its endosymbiont, Wolbachia
Fig 5
Analysis of transcriptomic data obtained from B. malayi L3, L4 and adult worms.
A. Gene expression of PyrK (Bm3590) responsible for the final step in glycolysis (conversion of P-PEP to pyruvate). B. Gene expression of LDH (Bm3339) responsible for the conversion between lactate and pyruvate. C. Gene expression of HIF-1 (Bm3907), transcriptional factor that initiates the expression of glycolytic enzymes. D, E, F. Gene expression of PyrDH (Bm9000 (D), Bm7953 (E), Bm3652 (F)) responsible for the conversion of pyruvate to Acetyl-CoA. ***–p<0.001 as compared to L3 samples.