Chromatin dynamics and the transcriptional competence of HSV-1 genomes during lytic infections
Fig 7
All HSV-1 genes resolved together to the least and most accessible chromatin fractions as infection progressed.
(A) Cluster analyses of the number of DNA reads from IE, E and L genes in each fraction. Cluster analysis was performed using Cluster 3.0 from Stanford University, visualized with Java Treeview. (B) Bar graphs showing sampling of each HSV-1 genes at 2h, 4h, and 15h after infections. Sampling of each HSV-1 gene was calculated and normalized to the sampling of the gene in the undigested and unfractionated chromatin. The sampling of each gene was plotted according to kinetic class. Blue, IE genes; black, E genes; dark purple, unclassified L genes; light purple, early L genes; brown, true L genes; grey, unclassified genes. Ins, insoluble chromatin fraction. Results from one experiment representative of two.