Lung transcriptional unresponsiveness and loss of early influenza virus control in infected neonates is prevented by intranasal Lactobacillus rhamnosus GG
Fig 5
Sham-treated neonates begin to respond 24 hours post-infection.
LGG or sham treated animals were either mock or influenza infected on Day 3 of life. Animals were harvested 24 hours post-infection. Nanostring gene transcription analysis was performed on whole lungs. (A) Heatmap of all genes assayed in the LGG-treated neonates, compared to expression in all other groups. Green: Up regulated; Brown: Down regulated. N = 3 per group. (B) Principal component analysis of both 12 and 24 hours post infection samples.