Latency reversal agents affect differently the latent reservoir present in distinct CD4+ T subpopulations
Fig 3
Proportion of CD4+ T cells expressing the viral protein p24 after viral reactivation with different LRAs.
A. The proportion of HIV-transcribing CD4+ T cells that simultaneously produce the viral protein p24 is shown. Comparisons with the control medium were performed using the Wilcoxon test. *p<0.05, **p<0.01. B. Calculation of synergistic, antagonistic or additive effect after the combination of LRAs using the Bliss independence model. White symbols correspond to patients in which production of p24 was not detected. Medians and min to max ranks are represented in panels A and B. C. Normalization of the percentage of HIV-transcribing cells expressing p24 relative to PMA/Ionomycin. Pies for individual patients and median values for all patients are represented in a box and whisker plot graph. Fractions of HIV-1 RNA+ cells expressing p24 and lacking the expression of p24 are shown in orange and blue, respectively.