Metal-independent variants of phosphoglycerate mutase promote resistance to nutritional immunity and retention of glycolysis during infection
Fig 5
GpmA is necessary for invasive S. aureus disease and resisting manganese starvation.
Wild type C57BL/6 (C57) and CP-deficient C57BL/6 S100A9-/- (CP-/-) mice were infected with either S. aureus wild type, ΔgpmA or ΔgpmI and (A) mean weight loss and (B-C) bacterial burdens in the (B) liver and (C) heart and kidneys were assessed after four days of infection. (A) *,# = p≤0.05 as determined by two-way ANOVA with Tukey’s multiple comparisons test, with * compared to wild type bacteria and # compared to ΔgpmI. (B-C) * = p≤0.05 as determined by Mann-Whitney test for bacterial burdens. The lines indicate the mean. The data are the results from two independent experiments.