Metal-independent variants of phosphoglycerate mutase promote resistance to nutritional immunity and retention of glycolysis during infection
Fig 3
Expression of a metal-independent isozyme facilitates retention of glycolysis when manganese-starved.
(A-D) S. aureus wild type, ΔgpmA and ΔgpmI were grown in defined medium supplemented with (A) glucose (DM + glucose), (B) Casamino acids (DM + AA), (C) glucose and sodium pyruvate (DM + glucose + pyruvate) or (D) glycerol (DM + glycerol) as a carbon source in the presence of increasing concentrations of CP (t = 7). * = p≤0.05 relative to wild type and ΔgpmI by two-way ANOVA with Tukey’s multiple comparisons test. n≥3. Error bars indicate SEM. Also see S2 Fig.