Equine arteritis virus long-term persistence is orchestrated by CD8+ T lymphocyte transcription factors, inhibitory receptors, and the CXCL16/CXCR6 axis
Fig 2
Differential gene expression profile in the ampullae of long-term (n = 3) and short-term (n = 6) EAV carrier stallions compared to the naïve group (n = 3).
(A) The Venn diagram depicts the differentially expressed genes (DEGs) common between long-term and short-term carrier stallions, with a clear majority being upregulated. (B and C) GO analysis (biological process and molecular function) of commonly upregulated genes between long-term and short-term carrier stallions reveal involvement in biological processes associated with cell adhesion, extracellular matrix organization, response to wounding, integrin signaling, among others, with a high proportion of genes presenting binding and catalytic activities. (D) Significant pathways associated with commonly upregulated genes.