STING is required for host defense against neuropathological West Nile virus infection
Fig 6
STING-/- have a defective adaptive immune response in the CNS during WNV infection.
(A) Cellular infiltrate in the brain in Terminal and Survivor mice by pathological review of H&E. n = 3–5. (B) CD3 IHC of WNV infected brains. Boxed regions, higher magnification, lower panel. T cells stain brown; hematoxylin counterstain. (C-H) Flow analysis of brain lymphocytes. Left: frequency; Right: Absolute number. N = 3–5 per condition. Unpaired students t-test; p = 0.05*; p = 0.005*; p = 0.0005***). (I) CD4/CD8 ratio in the brain. (J) Flow gating scheme. (K) FoxP3+CD25+CD4 T cells in brains. Left: frequency; Right: Absolute number. N = 3–5 per condition. Unpaired students t-test; p = 0.05*; p = 0.005*; p = 0.0005***).