Non-canonical NLRP3 inflammasome activation and IL-1β signaling are necessary to L. amazonensis control mediated by P2X7 receptor and leukotriene B4
Fig 7
ATP activates the P2X7 receptor, which in turn leads to the production and release of LTB4. LTB4, through a mechanism as yet unknown, activates Casp-11. Casp-11 activates the NLRP3 inflammasome, leading to maturation of Casp-1. Casp-1 cleaves pro-IL-1β into mature IL-1β as it is released into extracellular medium and activates IL-1 receptors. By a mechanism as yet unknown, activation of IL-1R leads to the control of L. amazonensis in macrophages.