Histamine release from intestinal mast cells induced by staphylococcal enterotoxin A (SEA) evokes vomiting reflex in common marmoset
Fig 8
Stimulation of vomiting by SEA is transmitted via the vagus nerve.
Vagotomized (n = 6) and sham operated (n = 6) common marmosets were administered 40 mg/kg of copper sulfate (left panel). Alternatively, vagotomized (n = 6) and sham-operated (n = 8) common marmosets were administered 250 μg/kg of SEA (right panel). (A) The emetic response (percentage of vomited monkeys) and (B) its frequency were assessed as described in materials and methods. Each bar represents the mean ± SD. The statistical analysis was performed using Fisher’s exact test and the Mann-Whitney U test, *P<0.05.