Histamine release from intestinal mast cells induced by staphylococcal enterotoxin A (SEA) evokes vomiting reflex in common marmoset
Fig 5
SEA induces degranulation of mast cells.
Specimens of the intestinal tract were removed from a common marmoset at 2 h post-injection with 500 μg of SEA in the intestinal loop. (A) The number of metachromatic-staining cells in toluidine blue-stained jejunum sections was counted from 6 randomly selected areas. The number of submucosal metachromatic cells per square millimeter are presented as the mean ± SD, *P<0.05. (B) The jejunum sections in the intestine loop at 2 h after SEA or PBS injection were stained with toluidine blue. Mast cells are indicated as arrowheads in the SEA-injected loop and as arrows in the PBS-injected loop. The statistical analysis was performed using the Mann-Whitney U test.