STAT2 dependent Type I Interferon response promotes dysbiosis and luminal expansion of the enteric pathogen Salmonella Typhimurium
Fig 7
16S rRNA profiling of the microbiome from the S. Typhimurium infected wild-type and Stat2-/- mice following 5 weeks of co-housing.
A. Phylum level microbiota composition was determined in uninfected and infected C57BL/6 and Stat2-/- mice through 16S rRNA analysis in fecal DNA samples as well as B. cecal DNA samples. C. Relative abundance of Bacteroidetes was determined in fecal DNA samples from uninfected and infected C57BL/6 and Stat2-/- mice D. Relative abundance of Proteobacteria was determined in fecal DNA samples from uninfected and infected C57BL/6 and Stat2-/- mice. E. CFU/g of S. Typhimurium was enumerated in the colon contents of C57BL/6 and Stat2-/- mice 48 hours post infection. Mean and SE were calculated by averaging results *p <0.05, as determined by Students t-test.