STAT2 dependent Type I Interferon response promotes dysbiosis and luminal expansion of the enteric pathogen Salmonella Typhimurium
Fig 5
Bacterial burdens in various organs in C57BL/6 and Stat2-/- infected mice following S. Typhimurium infection.
C57BL/6 and Stat2-/- mice were orally infected with 109 CFU of S. Typhimurium following streptomycin pretreatment. Forty-eight hours following infection mice, were euthanized and the colon contents, cecum, mesenteric lymph nodes (MLN), and spleen were collected and plated for bacterial enumeration. Mean and SE were calculated by averaging results from three independent experiments. *p <0.05 as determined by Students t-test.