STAT2 dependent Type I Interferon response promotes dysbiosis and luminal expansion of the enteric pathogen Salmonella Typhimurium
Fig 2
Survival of C57BL/6, Stat2-/- and Stat1-/- mice after oral S. Typhimurium infection.
Percent survival of C57BL/6 (n = 18) black line, Stat1-/- (n = 11) red line, and Stat2-/- (n = 13) blue line mice for 8 days post oral 109 Salmonella Typhimurium infection following streptomycin pretreatment. The results from three independent experiments with at least 3 mice in each group were combined. Stat2-/- infected mice survived significantly longer, p = 0.0026.