The possible role of cross-reactive dengue virus antibodies in Zika virus pathogenesis
Fig 2
Results from in vivo studies investigating the role of ZIKV antibodies in DENV infection and on DENV antibodies in ZIKV infection.
Left panel: In mice that had ZIKV antibodies either maternally acquired or administered before DENV infection, increased DENV viral load, cytokine production, and mortality was observed. In macaques that were previously infected with ZIKV, an increased DENV viral load but no clinical symptoms or mortality was observed upon infection with DENV. Right panel: In some DENV-preimmune mice that were infected with ZIKV, an increased viral load and cytokine production but not mortality was observed. In DENV-preimmune macaques infected with ZIKV, no changes in viral load, cytokine production, or mortality was observed in DENV. ADE, antibody-dependent enhancement; DENV, dengue virus; ZIKV, Zika virus.