Central memory CD8+ T cells become CD69+ tissue-residents during viral skin infection independent of CD62L-mediated lymph node surveillance
Fig 5
Circulating memory CD8+ T cells become CD69+ TRM following local antigen recognition in the skin.
(A) LCMV-immune mice were infected with VacV-GP33 on the left ear skin and VacV-OVA on the right. On day 15 post-infection, total number of memory P14 CD8+ T cells in the skin were quantified. (B) CD69 expression on memory P14 CD8+ T cells from (A). (C) Quantification of (B). (D) On day 40 post-infection, the number of CD69+ memory P14 CD8+ T cells was quantified in the left and right ear skin.