Recurrent herpes simplex virus-1 infection induces hallmarks of neurodegeneration and cognitive deficits in mice
Fig 5
Multiple HSV-1 reactivations induce Aβ accumulation and deposition in amyloid plaques.
(A) Representative images of immunoperoxidase staining of Aβ40/42 in coronal brain slices from HSV1-M and CTRL-M undergone 7 TSs. (B) Thioflavin-S (ThS) staining (green) in brain slices from mice undergone 7 TSs. Representative images of CTX, CA1 and DG are shown from 1 out of the 3 studied mice. As positive control the same analysis was performed on brain slices from 9-month-old 3×TgAD mouse. Arrowheads indicate plaques, dotted lines delimitate pyramidal neuron layer in CA1 and granule cell layer (GCL) between molecular layer (mol) and hilus in DG. Scale bars: 50 μm.