Modeling the measles paradox reveals the importance of cellular immunity in regulating viral clearance
Fig 6
Comparing the dominant driver of viral clearance across individuals.
For each macaque, the impacts of T cell depletion and target cell addition on viral load were calculated as the difference in the area under curve (AUC) between the experimental and control simulations, normalized by the AUC of the control simulation. Results for each individual are indicated by the corresponding identification code and the dashed line signifies the y = x boundary where experimental effects are equal. Simulations were conducted for (A) MV (by using best-fit parameters from the original target cell and T cell model); and (B) a virus with increased fitness (by doubling each individual’s viral replication rate, p). All axes are depicted on the log scale.