Roles of GP33, a guinea pig cytomegalovirus-encoded G protein-coupled receptor homolog, in cellular signaling, viral growth and inflammation in vitro and in vivo
Fig 10
BAC-derived GPCMV strains showed attenuated phenotypes.
Pregnant guinea pigs (Hartley) at 4 weeks’ GA were infected s.c. with GPCMVΔ9K WT or with GPCMV SG (n = 4 each; 3x106 IUs/animal) and sacrificed at 6 days p.i. to collect specimens. (A) Images of the lungs obtained from the dams infected with GPCMVΔ9K WT (upper row) or GPCMV SG (lower row) are shown in the order of abnormalities in appearance from most severe to mildest. (B) An image of the liver with necrotic lesion that was obtained from one of the dams infected with GPCMV SG. (C-F) GPCMV genome copies per 106 cells of the spleens (C), livers (D), lungs (E), and salivary glands (F) obtained from the dams infected with GPCMVΔ9K WT (open circles) or GPCMV SG (squares). Means and SEMs are shown.