Roles of GP33, a guinea pig cytomegalovirus-encoded G protein-coupled receptor homolog, in cellular signaling, viral growth and inflammation in vitro and in vivo
Fig 8
Viral loads in organs at 3 weeks after infection of dams at 4 weeks’ GA.
(A, B) Pregnant guinea pigs (Hartley) at 4 weeks’ GA were infected s.c. with GPCMV r33 or Δ33 (n = 4 each; 2x107 IUs/animal) and sacrificed at 3 weeks p.i. to collect specimens. Comparison of the weights of placentas (A) and fetuses (B) from dams infected with r33 (open circles) or Δ33 (closed circles). Each circle indicates one placenta or fetus. Means and SEMs of the weights are shown. (C-F) GPCMV genome copies per 106 cells of the livers (C), lungs (D), spleens (E), and salivary glands (F) obtained from the dams infected with r33 (open circles) or Δ33 (closed circles). Means and SEMs of genome copies are shown. (G-I) GPCMV genome copies per 106 cells of the placentas (G), fetal livers (H) and fetal lungs (I) obtained from fetuses of the dams described above. Means and SEMs of genome copies are shown.