Roles of GP33, a guinea pig cytomegalovirus-encoded G protein-coupled receptor homolog, in cellular signaling, viral growth and inflammation in vitro and in vivo
Fig 5
Viral loads in organs at 6 days after infection of dams at 4 weeks’ GA.
Pregnant guinea pigs (Hartley) at 4 weeks’ GA were infected s.c. with GPCMV r33 or Δ33 (n = 4 each, 2x107 IUs/animal) and sacrificed at 6 days p.i. to collect specimens. (A) Relative body weights of dams infected with r33 (open circles) or Δ33 (closed circles) (n = 4 each) are shown using the body weight of each animal at the time of GPCMV infection as a 100% control. Comparison of the weights of placentas (B) and fetuses (C) from dams infected with r33 (open circles) or Δ33 (closed circles). Each circle indicates one placenta or fetus. Means and SEMs are shown. (D-H) GPCMV genome copies per 106 cells of the indicated organs from the animals infected with r33 (open circles) or Δ33 (closed circles). Means and SEMs are shown. (I) GPCMV genome copies per 106 cells of the placentas obtained from the dams described above.