Polymicrobial sepsis influences NK-cell-mediated immunity by diminishing NK-cell-intrinsic receptor-mediated effector responses to viral ligands or infections
Fig 13
IL-2c therapy numerical recovery of Ly49H+ NK-cells partially rescues MCM viral control in CLP hosts.
(A) Experimental Design. One day after surgery mice were treated with IL-2c or IgG (control) and infected with MCMV 6 days later. Number of Ly49H+ NK-cells in the PBL of Sham (B) and CLP (C) mice at the time of MCMV infection. Viral titers in the spleens (D) or livers (E) of Sham and CLP groups of mice. Data are representative from 3 independent experiments with 3–5 mice per group. * p<0.05. Error bars represent the standard error of the mean.