Polymicrobial sepsis influences NK-cell-mediated immunity by diminishing NK-cell-intrinsic receptor-mediated effector responses to viral ligands or infections
Fig 10
Sepsis impairs NK-cell-mediated MCM viral control.
(A) Experimental Design. NK-sufficient or–deficient (IgG and α-NK1.1-treated, respectively) groups of mice were infected with the Smith strain of MCMV (105 PFU, i.p.) 2 days post-Sham or CLP surgery. Viral titers in the spleens (B) or livers (C) of Sham and CLP groups 3 days after MCMV infection. (Data are representative from 3 independent experiments with 3–5 mice per group. * p<0.05. Error bars represent the standard error of the mean.