Polymicrobial sepsis influences NK-cell-mediated immunity by diminishing NK-cell-intrinsic receptor-mediated effector responses to viral ligands or infections
Fig 3
Gene-set enrichment analysis (GSEA) reveals sepsis-induced changes in molecular pathways relevant to NK-cell effector functions.
(A) Enrichment scores of genes in pathways relevant to sepsis (apoptosis) and NK-cells functionality (NK-mediated cytotoxicity and calcium signaling). Red box indicates leading edge of enriched region; negative enrichment—box to left, positive enrichment—box to right. Gene expression heatmap and core enrichment of genes in NK-cell-mediated Cytotoxicity (B) and Calcium Signaling (C). Gene expression heatmap of core enriched genes in NK-cell-mediated Cytotoxicity (D) and Calcium Signaling (E).