Polymicrobial sepsis influences NK-cell-mediated immunity by diminishing NK-cell-intrinsic receptor-mediated effector responses to viral ligands or infections
Fig 2
Sepsis induces significant transcriptional changes in NK-cells.
(A) Experimental Design. Mice were sacrificed at day 1 or 2 post-Sham or CLP surgery and NK1.1+/CD3- NK-cells FACS-sorted from the spleen before RNA extraction. (B) Gene expression heatmap of genes with statistically significant change (Fold change greater than or equal to 1.5 and p<0.05) as a result of any combination of comparison. (C) Number of statistically significant gene changes as a result of each comparison. (D) Principal component analysis of significantly changed genes.