An anti-Gn glycoprotein antibody from a convalescent patient potently inhibits the infection of severe fever with thrombocytopenia syndrome virus
Fig 3
Delayed administration of Ab10 also protected mice from SFTSV infection up to 3 days after inoculation of the virus.
The overall scheme for the virus challenge and delayed antibody administration is described in (A). Eight-week-old A129 mice (n = 5 per group) were inoculated with 2 or 20 PFU of SFTSV through a subcutaneous route. From 1, 3, 4, or 5 days post-infection, infected mice were intraperitoneally administered with 600 μg of Ab10 per day for 4 consecutive days. Percentages of survival (B) and weight relative to the day of virus inoculation (C) were monitored daily until 10 days post-infection. Survival was determined by the Kaplan-Meier method. The values in (C) are presented as the means with standard deviations of surviving mice in each group.