An anti-Gn glycoprotein antibody from a convalescent patient potently inhibits the infection of severe fever with thrombocytopenia syndrome virus
Fig 2
Ab10 protected mice from SFTSV infection.
The overall scheme for the administration of virus and antibody is described in (A). Eight-week-old A129 mice (n = 5 per group) were inoculated with 2 or 20 PFU of SFTSV through a subcutaneous route. At 1, 24, 48, and 72 h post-infection, infected mice were intraperitoneally administered with 600 μg of Ab10, MAb4-5, IgG1 isotype control antibody, or PBS vehicle control. Percentages of survival (B) and body weight relative to the day of virus inoculation (C) were monitored daily until 10 days post-infection. Survival was determined by the Kaplan-Meier method. Relative body weight values in (C) are presented as the means with standard deviations of surviving mice in each group.