Mitochondrial protein import in trypanosomatids: Variations on a theme or fundamentally different?
Fig 3
Comparison of the inner membrane protein translocases TIM23 and TIM22 of S. cerevisiae with the single T. brucei TIM complex.
Tim22 and TbTim17 are orthologues and are indicated in orange. Other subunits are shown in light grey. The peripherally associated small TIM and the PAM complexes are indicated in dark grey. The composition of the trypanosomal PAM is unknown at present. The two inactive rhomboid-like proteases, TimRhomI and TimRhomII, were specific for the presequence translocase. The depiction of the trypanosomal TIM complex is schematic; its exact architecture remains to be elucidated. ACAD, acyl-CoA dehydrogenase; IM, inner membrane; PAM, presequence-associated motor; Sdh, succinate dehydrogenase; TIM, translocase of the IM.