A bispecific immunotweezer prevents soluble PrP oligomers and abolishes prion toxicity
Fig 1
A bispecific immunotweezer formed by a combination of toxic (POM1) and non-toxic (POM2) antibodies.
(A) The single chain variable domains of POM1 and POM2 are joined by a flexible linker to yield the bispecific scPOM-bi, schematic representation. B) Computational molecular dynamics model of scPOM-bi in complex with mPrP; intra-molecular (left and S1 Movie) and inter-molecular (right and S2 Movie) binding modes are shown. They are both structurally accessible to scPOM-bi.