Genome-wide analysis of regulatory G-quadruplexes affecting gene expression in human cytomegalovirus
Fig 1
Schematic representation of the positions of genes and predicted 36 GQs associated with the putative promoter or regulatory regions in the HCMV genome.
Among 38 GQs (GQ1~GQ38), which were initially annotated between -500 and +100 with respect to the translation initiation sites of genes (S1 Table), 36 GQs that were analyzed in this study are presented in the diagram. The x-axis represents the genomic scale or base positions. Two strands of HCMV DNA are separately shown as parallel lines. Approximate locations and strand positions of GQs are shown with open circles. Location and orientation of the associated genes are indicated as black bar pointers between the two strands. The types of G4s are differentiated by different font colors: type-I (conventional), blue; type-II (long-loop), black; and type-III (bulged), red. The unique long (UL) and unique short (US) regions of the HCMV genome and the terminal and internal repeat regions (open boxes) are indicated at the top of the figure.