Exploitation of nuclear functions by human rhinovirus, a cytoplasmic RNA virus
Fig 9
Proposed model of HRV16-SFPQ interactions during the infectious cycle.
Following translation of viral proteins, HRV16 3CD/3C enters the nucleus where it targets SFPQ for cleavage at Q257 within the N-terminus. Cleavage releases SFPQ from interactions with nuclear-resident anchors such as DNA and allows the C-terminal fragment to migrate to the cytoplasm through degraded nuclear pore complexes. Once in the cytoplasm, the SFPQ fragment interacts with HRV16 RNA, directly or through other protein partners, and may promote viral replication.