Type I IFN signaling blockade by a PASylated antagonist during chronic SIV infection suppresses specific inflammatory pathways but does not alter T cell activation or virus replication
Fig 6
T cell activation/exhaustion and subsets frequencies.
(a) Peripheral blood frequency of CD38+, HLA-DR+ and Ki67+ CD8 memory T cells, (b) Frequency of LAG3+, PD-1+ and TIGIT+ CD8 memory T cells and (c) Peripheral blood CD4:CD8 ratio and frequency of peripheral blood CCR5+ memory CD4 T cells in ART-untreated or ART-treated macaques that received placebo saline, IFN-1ant injections 2 times weekly (IFN-1ant2x) or 3 times weekly (IFN-1ant3x). Error bars represent IQR. P values were calculated between groups by Mann–Whitney U test.