Type I IFN signaling blockade by a PASylated antagonist during chronic SIV infection suppresses specific inflammatory pathways but does not alter T cell activation or virus replication
Fig 1
35 rhesus macaques received intrarectal challenge with SIVMAC251 at baseline. At week 8 post-infection (p.i.), 25 animals received ART and 10 animals remained untreated. From week 16 to week 24 p.i., ART untreated SIV-infected animals received placebo saline (group 1, n = 4) and PASylated IFN-1ant 3 times per week (group 2, n = 6). ART-treated SIV-infected macaques received placebo saline (group 3, n = 9), PASylated IFN-1ant 2 times per week (group 4, n = 11) or 3 times per week (group 5, n = 5) from week 16 to week 24 p.i.. About 25 weeks after IFN-1ant, ART was interrupted and all animals monitored for an additional 15 weeks.