Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri
Fig 6
Sequence alignments between the catalytic domain of sterol Δ8−Δ7 -isomerase (ERG2) and a ligand binding site of non-opioid σ1 receptor (SGMR1) demonstrate high sequence similarity.
Accession numbers in UniProt or AmoebaDB are provided for each sequence. Numbering is according to the Dictyostelium discoideum ERG2 sequence.