Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri
Fig 4
Growth inhibition of N. fowleri as a function of drug combinations.
Heat maps show growth inhibition of N. fowleri by drug combinations: tamoxifen and isavuconazole (A), epiminlanosterol and tamoxifen (B), and epiminolanosterol and isavuconazole (C). Corresponding isobolograms (D, E, F) show the mean values of dose reduction index (DRI) ploted against calculated inhibitor doses required to achieve 95% growth inhibition. Standard deviations for each parameter mean value are shown in S2 Table.