Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri
Fig 3
Dose-response growth inhibition of N. fowleri trophosoites.
Dose-response curves are shown for (A) SMT inhibitors: abafungin, 25-azacycloartenol and 24,25-epiminolanosterol, (B) ERG2 inhibitors: tamoxifen and AY9944, (C) CYP51 inhibitor isavuconazole.